Translational Relevance

A brief overview of the 33rd Annual STP Symposium on the translational pathology: relevance of toxicologic pathology to human health.

The 33rd Society of Toxicologic Pathology's Annual Symposium focused on translational science and the relevance of toxicologic pathology to human health. Toxicologic pathologists work in diverse settings studying changes elicited by pharmacological, chemical, and environmental agents and factors that modify these responses. Regardless of the work setting, society members are dedicated to the in...

MicroRNAs: Critical Regulators of mRNA Traffic and Translational Control with Promising Biotech and Therapeutic Applications

Context:MicroRNAs (miRNAs) are a class of short, endogenously-initiated, non-coding RNAs that post-transcriptionally control gene expression via translational repression or mRNA turnover. MiRNAs have attracted much attention in recent years as they play critical roles in gene expression and are promising tools with many biotech and therapeutic applications. The molecular mechanisms und...

TRANSLATIONAL PHYSIOLOGY Expression of sweet receptor components in equine small intestine: relevance to intestinal glucose transport

Expression of sweet receptor components in equine small intestine: relevance to intestinal glucose transport Kristian Daly,* Miran Al-Rammahi,* Daleep K. Arora, Andrew W. Moran, Christopher J. Proudman, Yuzo Ninomiya, and Soraya P. Shirazi-Beechey Epithelial Function and Development Group, Department of Functional and Comparative Genomics, Institute of Integrative Biology, Faculty of Health and...

Translational genomics

The term "Translational Genomics" reflects both title and mission of this new journal. "Translational" has traditionally been understood as "applied research" or "development", different from or even opposed to "basic research". Recent scientific and societal developments have triggered a re-assessment of the connotation that "translational" and "basic" are either/or activities: translational r...

Desorption of hot molecules from photon irradiated interstellar ices

We present experimental measurements of photodesorption from ices of astrophysical relevance. Layers of benzene and water ice were irradiated with a laser tuned to an electronic transition in the benzene molecule. The translational energy of desorbed molecules was measured by time-of-flight (ToF) mass spectrometry. Three distinct photodesorption processes were identified: a direct adsorbate-med...

Arthritogenicity of Type II Collagen Relevance of Posttranslational Modifications